r.Mono usually is caused by the Epstein-Barr virus (EBV). It is most often seen in teens and young adults. Children can get the virus, but it often goes unnoticed because their symptoms are mild. Older adults usually don t get mono, because they have immunity to the virus. Usually only self-care is needed for mono. - Get plenty of rest. he may need bed rest, which could keep him away from school or work for a little while. -.Gargle with salt water or use throat lozenges to soothe his sore throat. . - Take acetaminophen or ibuprofen to reduce fever and relieve a sore throat and headaches. Never give aspirin.you can give domperidone or omeprazol for vomiting /gastric upset. - Avoid contact sports and heavy lifting. His spleen may be enlarged, and an impact or straining could cause it to burst(severe pain in the upper left part of your belly may mean that your spleen has burst. This is an emergency.) -- avoid drugs like Ampicillin and amoxicillin. - In severe cases, medicines called corticosteroids may be used to reduce swelling of the throat, tonsils, or spleen. mono, is a common illness that can leave him feeling tired and weak for weeks or months. Mono goes away on its own, but lots of rest and good self-care can help him feel better.