My brother (26 years), was diagnosed with Reactive Arthritis 6 years ago. He tested positive for HLA B27. He consulted a doctor and has been taking Sazo 500 since then. He has been keeping fine all these long (no pains). Initially he was taking 4 tablets per day, after some time he reduced it to 2 tablets and then to 1 tablet a day. He got married last year and has been planning for a child since Feb 2010. Hence he stopped taking Sazo since Feb 2010. His wife conceived in Sept 2010 and he started taking back Sazo from Oct 15, 2010. But since Nov 2010 he has started experiencing pain in his hip. In Nov 2010 he consulted a Rheumatalogist. He was asked to get an Xray of his hip and few blood reports. All the blood tests were normal but there was some problem/effect of arthritis in his hip. He started taking 4 tablets of Sazo 500 after that and has also been doing regular exercise everyday for 1 hr - 1.5 hr. I want to know that what effects arthritis can have in his body. Can the disease disable him? I know that arthritis has no cure, but how can he improve the quality of his life. What are the worst effects that arthritis can have in his body? How can he lead a normal healthy life?