Hello,
Thanks for the query,

Psoriasis cannot be totally cured.

It can be only controlled.

You can use steroid creams to control this.

Please meet a dermatologist for exact diagnosis.

And get the medication prescribed.

Let me know if you have any other doubt.

you can ask a direct question to me on this forum, following the below link.
http://www.healthcaremagic.com/doctors/dr-rahul-kumar/64818

Wishing you good health,
Thank you

Hello. Thank you for writing to us at healthcaremagic

Psoriatic patches involving palms and soles is not going to interfere with day to day activities but also fissuring and cracking would make hand movement painful.
Frequent use of moisturizers, softens thick scaly plaques and help seal cracks and fissures.
Apart from moisturizers, potent topical steroid creams e.g clobetasol propionate 0.05% with or without salicylic acid, are specific treatment for thick scaly psoriatic patches involving palms.
You have already been using it.
However, topical treatment alone may not be effective in alleviating the problem completely and moreover topical treatment modalities may take time to produce noticeable improvement in the patches.
In my view, Oral Methotrexate is an option for psoriatic patches involving palms.
Though this drug is mainly used for widespread body involvement with psoriasis but in those cases with incapacitating involvement of palms, it is definitely indicated.
It is a prescription drug and therefore I suggest you to talk to your dermatologist for the needful.

Regards