Hi, Thanks for writing to Health Care Magic, I am Dr Asad Riaz, I have closely read your question and I understand your concerns, I will hereby guide you regarding your health related problem. Zoloft contain SSRI(sertraline) is used for deprsion or other pyschiatry disorder like OCD etc... this drug action can be affected by many other drugs , azithromycin don t interact with it... these type of feature either can be due to infection n fever or can be side effects of this drug ... if u were my patient I would like to evaluate that is this drug is the culprit that causing these features n will optimise dose n still having same feature then wil switch to alternative or if this is due to Bcs of underlying disease will manage it n if it due to due to azithromycin or strep induce then will Manage it accordngly ... I hope this answered your question, if you have more feel free to ask. Regards. Dr.Asad Riaz. General and Family Physician..