My wife is suffering from membranous nephropathy. She is undergoing treatment for the last one year. Urine spot protein is > 750 mg/dl and urine spot creatinine is > 100 mg/dl. Urine spot prot/Creat Ratio is > 14/1 during the last month. Still she was OK and was moving. For the last three days she has become very sick. She has severe pain in the kidney region. Whole body is paining. Not able to get up from the bed. Kindly give me guidance.