I had my second Prolia injection in early December 2013. About 2 weeks later, I began to experience severe cramping in my left foot, along the inside edge below the big toe, when I was laying in bed at rest. It would awaken me at night or prevent me from going to sleep. It was like a charley-horse cramp; massaging the area would help relieve it temporarily. There was no pain when walking or standing so sometimes I would get up and walk around, hoping I could get back to sleep if the cramps subsided. Next I began to feel pain in the big toe of each foot, it would cramp and feel like the bone would break if I bent it. I m still suffering from the cramps and pains only now I feel them occasionally during the day while engaged in other activities. I m wondering if it could be a Prolia side effect and if there is any medication to alleviate the severe cramps. (My doctor tested me for gout and it was negative. I ve tried Ibuprofen with minimal relief. I was taking Zetia and stopped taking it 6 weeks ago, thinking it might be the cause, but I m still having this problem so now I m wondering if it s due to the Prolia.)