Yes. My wife has been giving me testosteron, Bcomplex and B3 injections in the quad muscles. It went fine for almost 3 months. The 2nd to the last shot cause debilitating soreness, to the point I had great difficulty walking. There was minor flushing of the skin in the area, but it didn t travel like an injection. It happened again this week. Also, I m breaking out in acne all over my arms, neck and shoulders. I wrapped the thigh, and put novocaine patches on. I don t knoww id they helped. Correction; they were Lidoderm patches Should I try the shoulders or buttocks?