Hello Manish , Hope your wife is taking appropriate treatment for asthma (steroid inhalers ) and hypothyroidism ( thyroxine tablets). No supplement can substitute the correct treatment. Was your wife forced to take all these supplements because she was not getting adequate relief with prior treatment? Regarding safety of these supplements nutrilite tripple guard - it is claimed to contain extract of the plant Echinacea, a central american herb. This plant is claimed to boost immunity and thus prevent common cold. Your wife is suffering from asthma , not common cold. There are reports of worsening of autoimmune disease after taking Echinacea So your wife should stop taking this product. You may try tulsi leaf if available . Must be cheaper than Echinacea nutrilite daily - it contains 24 vitamins and minerals similar to the multivitamin tablets available over the counter ( like cobadex czs , polybion czs , surbex xt , reconia etc) . Will not be harmfull . She may continue to take it Bio C - it conatins 250 mg vitamin C the daily requirement is 60 mg only you are already getting 90 mg from nutrilite daily. So unnecessary siberian ginseng with ginkgo biloba - they claim it improves mental sharpness Not necessary for your wife s current disease. I would suggest you give priority to optimal treatment than spending thousands on supplements. Consult a pulmonologist and endocrinologist. Also discuss regarding possibility of sleep apnea