can cause vit D deficiency with the resultant calcium deficiency
as vitamin D is needed for the calcium metabolism
and vitamin D deficiecy leads to calcium deficiency.
Data on valproate (VPA) effects on folic acid
are conflicting. Most authors report that valproate does not reduce folate levels but may interfere with folate metabolism by inhibiting glutamate formyl transferase, an enzyme mediating the pathway that produces folinic acid