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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suffering From Bone Pain. Diagnosed With Cirrhosis, Hypothyroidism And Thrombocytosis. Born Marrow Biopsy Normal. ANA Positive And AMA Negative. What Does It Mean?

hi i am 34 years old lady with chief complaint of bone pain especially in fist left metacapofalengeal joint and thumbsince 1 week ago . previously on medical work up it was detected that i have cirhosis(primary biliary cirhosis) , hypothyroidism & thrombocytosis . now in recent work up liver biopsy was done with inclusion of early stage of primary biliary cirhosis . bone marrow biopsy was normal and in lab data the significant thing was positive ANA and negative AMA would it be ok if you inform me about what is happening in my body?
Sat, 26 Oct 2013
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Internal Medicine Specialist,  's  Response
Hello I have taken note of your problems

Your problems might be due to two conditions
One is lupus as ANA is positive, but its only screening test you should confirm by getting anti ds DNA test..

Other one is autoimmune hepatitis in view of your hypothyroidism history, AMA is negative will not completely rule out the above condition. ..

I would suggest that you should hav a consultation with hepatologist and also get it done serum uric acid levels and CRP (c reactive protein) and Rheumatoid factor levels ...

Any queries please let me know, wish you speedy recovery. .

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Suffering From Bone Pain. Diagnosed With Cirrhosis, Hypothyroidism And Thrombocytosis. Born Marrow Biopsy Normal. ANA Positive And AMA Negative. What Does It Mean?

Hello I have taken note of your problems Your problems might be due to two conditions One is lupus as ANA is positive, but its only screening test you should confirm by getting anti ds DNA test.. Other one is autoimmune hepatitis in view of your hypothyroidism history, AMA is negative will not completely rule out the above condition. .. I would suggest that you should hav a consultation with hepatologist and also get it done serum uric acid levels and CRP (c reactive protein) and Rheumatoid factor levels ... Any queries please let me know, wish you speedy recovery. .