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Suffering from bone pain. Diagnosed with cirrhosis, hypothyroidism and thrombocytosis. Born marrow biopsy normal. ANA positive and AMA negative. What does it mean?

hi i am 34 years old lady with chief complaint of bone pain especially in fist left metacapofalengeal joint and thumbsince 1 week ago . previously on medical work up it was detected that i have cirhosis(primary biliary cirhosis) , hypothyroidism & thrombocytosis . now in recent work up liver biopsy was done with inclusion of early stage of primary biliary cirhosis . bone marrow biopsy was normal and in lab data the significant thing was positive ANA and negative AMA would it be ok if you inform me about what is happening in my body?
Asked On : Sun, 10 Jun 2012
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Internal Medicine Specialist 's  Response
Hello I have taken note of your problems

Your problems might be due to two conditions
One is lupus as ANA is positive, but its only screening test you should confirm by getting anti ds DNA test..

Other one is autoimmune hepatitis in view of your hypothyroidism history, AMA is negative will not completely rule out the above condition. ..

I would suggest that you should hav a consultation with hepatologist and also get it done serum uric acid levels and CRP (c reactive protein) and Rheumatoid factor levels ...

Any queries please let me know, wish you speedy recovery. .

Answered: Sat, 26 Oct 2013
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