Hello Thank you for getting in touch with us. As I see, you have a problem with acid reflux. It is a commonly seen problem worldwide. Your throat hurts as the acid during the reflux phase hits the back of the throat. That can cause pain and even hoarseness of voice. The drugs that you are taking (Prilosec and Prevacid) belong to the same category (proton pump inhibitors) and are recommended in gastroesophageal reflux disease. There is not much difference in these drugs. I would recommend you to get in touch with your physician. He would be able to analyze your problem and tell why the proton pump inhibitors are not working. if need arises, he can perform a surgery to tighten the sphincter so that no reflux takes place. Along with that, you should also consider changing your lifestyle and avoid nicotine, alcohol, caffeine and late night meals. Hope this helped Regards