Hello Fluticasone nasal spray is a well tolerated local steroid and side effects are very minor if taken in a proper doses with precautions. There can be:- Headache, nose bleed, sore throat or candida infection. To avoid nasal bleed don t spray on the septum ( a common trend is to spray by opposite side hand) Don t try to inhale deeply as this can cause sore throat. Rinse mouth well if you have inhaled it strongly. Stop the spray if you have some kind of viral infection particularly measles or herpes. Regards