Hi: Thank you for your question. First of all I want to make sure you have scabies. Sometimes patients get scaird and think they have scabies and it is not. I am assuming that you know this for sure. The cream has to be applied from head to toe (excluding your scalp and pubic hair, eyes, ears,). It needs to stay on 8-12 hours so I usually tell patients to do this before bed. The next morning they need to shower it off. Wash all bedsheets and clothing in very hot water. Check other family members for a rash. The itching will go on for a few more days as scabies is actually a mite which is a microscopic organism that burrows in the skin and lays eggs. You can use Benadryl which is over the counter. Vistaril requires a prescription. Some cases require a steroid because the itching goes on for weeks. If in one week, you still have lesions, the cream should be reapplied. Hope this helps, Carol Rogala D.O.