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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Reason for body pain if Indocin is stopped?

I have taken indocin for roughly 38 years for back pain. ( I have had 4 disc operations) I do not seem to have any adverse effects from the drug taking 75 mg once a day. Recently I was diagnosed having RA. My doctor has me taking 1500 mg Sulfasalazine daily and wants me to terminate the Indocin. Whenever I stop taking Indocin within two days my entire body hurts as if I was in a car wreck. I have read some of the adverse effects Indocin can have but its benefits for me are very high. Is it possible that after taking this medication for such a long time that my body has adapted to it or am I just as likely to experience the problems that Indocin may cause?
Tue, 26 Feb 2019
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Internal Medicine Specialist 's  Response
Hello,

Indomethacin(Indocin) is an NSAID and cause interstitial nephritis (Analgesic nephropathy) on long-term therapy.

It, however, does not cause any drug dependence. Switch over to safer analgesic like paracetamol.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Tushar Kanti Biswas, Internal Medicine Specialist
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