I have taken indocin for roughly 38 years for back pain. ( I have had 4 disc operations) I do not seem to have any adverse effects from the drug taking 75 mg once a day. Recently I was diagnosed having RA. My doctor has me taking 1500 mg Sulfasalazine daily and wants me to terminate the Indocin. Whenever I stop taking Indocin within two days my entire body hurts as if I was in a car wreck. I have read some of the adverse effects Indocin can have but its benefits for me are very high. Is it possible that after taking this medication for such a long time that my body has adapted to it or am I just as likely to experience the problems that Indocin may cause?