Dear User, Thanks for using healthcare magic. Generally alzheimer s do not present with white matter disease. The most common cause of white matter disease is ischemic injury. It is quite possible to have multiple small strokes if you are having ischemic disease risk factors like family history, hypertension, diabetes, smoking, factor V laden mutation. If you are having any risk factors you need to post again or contact your PCP for assessment of vascular risk factors and to find out the cause for white matter changes. Thanks