Hi, thanks for asking in Healthcare Magic. Rispond is Risperidone. It is an atypical antipsychotic drug. Nexito is Escitalopram. It is a selective serotonin reuptake inhibitor. Lonazep is Clonazepam. It is a Benzo diazepine. One of the side effect of Risperidone is postural hypotension (sudden fall in BP). But when combined with Escitalopram there will be an increase in BP. Since your friend has heart problems, this is not a proper combination. As an atypical antipsychotic drug, Risperidone can cause weight gain, increase in cholesterol level. In a Diabetic, weight gain will result in loss of control of the disease. Also the increase in cholesterol level will further worsen both Diabetes and heart problems. Although Escitalopram is the first drug of choice in chronic depression, when combined with Clonazepam it will increase the plasma levels of Clonazepam by inhibiting its metabolism. Clonazepam is more useful in anxiety rather than depression. Besides, as a Benzodiazepine, Clonazepam also causes increased appetite and weight gain. Instead of combining these three drugs Escitalopram alone can be given for your friend. Meclobamate is better tolerated option in mild to moderate depression especially suited in elderly with cardiac problems. I hope this is useful.