Thanks for posting your query.Methotrexate
over a period of time can damage liver and can case fibrosis
. It can cause a raise in the liver enzymes.
During methotrexate treatment, one should abstain from alcohol. Because it increases the risk of methotrexate induced liver injury
The liver enzymes would not have reached baseline within two weeks.
The ideal thing to do is to get a liver biopsy
done and proceed with methotrexate treatment only if the biopsy shows no changes or just grade I and II changes.
I hope that answers your question.