Thanks for writing in.
The instructions of "to be taken with a glass of water" are usually given as sometimes people find it difficult to swallow and there is a possibility of the tablet getting stuck. This can be easily avoided by taking it with a glass of water. If you take your tablet with a sip of water, there is no harm and it will not affect the way Nexium
is absorbed in your body.
But I hope you're taking atleasy 2-3 litres of water in a day to keep yourself hydrated.
Hope this helps.