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On chemotherapy for Multiple myeloma, on velcade, cycolphosmide, entecavir, baraclude. Advice?

Hello Dr and thankyou for taking this query. I am currently on chemotherapy for Multiple myeloma which was diagnosed before sympoms appeared - I 55 ys of age, female and under good care for my condition. I am taking lots of different drugs in conjunction with my velcade + cycolphosmide(?) treatment and just wanted to know what each is for as - particularly enteclovir and barachlude, (not sure of spelling) - can you help?
many thanks
Asked On : Thu, 17 Oct 2013
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General & Family Physician 's  Response
Welcome to Healthcaremagic.

Thanks for your query.
I have gone through your query and understand your concern.

Velcade contains Bortezomib.
It is proteosome inhibitor.
In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins, and also cleanses the cell of abnormal or misfolded proteins.
In myeloma cells, Bortezomib proteasome inhibition may prevent degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon suppression of pro-apoptotic pathways.

is a nitrogen mustard alkylating agent.
The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH.
Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively). This is irreversible and leads to cell death.

Entecavir is a Barculade.
Entecavir is a oral antiviral drug used in the treatment of hepatitis B infection.

Hope this helps. Please reply for further queries.
Wishing you good health.
Answered: Fri, 18 Oct 2013
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