Hello, I read your message and understood your problem. If it is possible for you to send me photos of your ankle it would be great. I need to see the lesion myself in order to give a final opinion. The ankle rashes can be due to a possible infection, autoimmune conditions, and other causes like lichen planus, Golfer s vasculitis and troubles with veins. Try to remember any insect bites or other things affecting the interested area. It is quite usual that the rash expands to upper parts of the legs. As keflex is working the skin infection soon will disappear and the red patch too. Soreness of legs indicates the presence of infection but not only this. You need to do a check to identify any problems with your leg veins like varicose veins or any rheumatologic conditions. Other health systems must be checked too especially kidney, liver and heart. Hope this is helpful. Dr.Albana