Hello, Welcome to HealthcareMagic forum, Duphaston which is progestogen can cause headache and breast tenderness. However pregnancy cannot be ruled out unless you find negative reports on home pregnancy test or blood hCG levels. You can get any of these tests done to rule out pregnancy. If pregnancy is ruled out, there could be other causes for absence of periods. A thorough pelvic examination, ultrasound examination and other test can narrow down the possibilities. You might be suggested to take oral contraceptive pill or dilatation and curettage procedure to induce menses. Hope this answers your query. Wish you good health. Regards