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Dr. Andrew Rynne

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My CMV Ig levels are positive, what does it mean ?

Hi, I am 33 years old female, pregnant 12 weeks. My CMV Ig levels are positive, concretely IgM 1.89 UI/ml and IgG 22. What does it mean? Is it riskest for my baby? Thank you Ann
Mon, 16 May 2011
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  User's Response
Hi Ann.



Thanks for the query.



CMV( cytomegalovirus) are commonly found all over the body but infect immunodeficient people. In Pregnancy it can be seen in primary case(newly infected cases) or reactivation in pregnancy(in previously infected people).



It doesn't produce any symptoms in healthy people while in immunocompromised people it can produce serious diseases like CMV retinitis, Hepatitis, Colitis, Pneumonia.



In pregnant women it can lead to Congenital abnormalities in the fetus if infected in the first trimester(12 weeks) of pregnancy. In your case, Your CMV IgG is positive along with IgM. IgM antibodies are seen positive in recent infections.



It would be better to see your GYNAEC and discuss about the prognosis of this infection. You might need to undergo further investigations to check for any congenital abnormalities in the fetus. If no congenital abnormalities found, pregnancy might be continued and has to be delivered through C-section.



Hope this answers your query.
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Pediatrician Dr. Suryakanta Baraha's  Response
hello ann,
serologic diagnosis of primary CMV infection during pregnancy is documented by eitherseroconversion (the appearance of CMV-specific IgG antibody in a previously seronegative woman) or detection of specific IgM antibody associated with low IgG avidity.
if u have detectable specific IgG antibodies without IgM antibodies before pregnancy and a significant rise of IgG antibody titre with or without the presence of specific IgMantibodies and with high IgG avidity can be classified as having recurrent infection.but you may not have previous records of the test.
if it is primary infection then there is 30 to 40 percent chance of intrauterine transmission to fetus with with delivery of 10% to 15% symptomatic newborns and late neurologic sequelae in 10% of those asymptomatic at birth.chance is bit higher if it is in 1st trimester.
so your next step is to diagnose fetal infection. Ultrasonographic findings are helpful but not diagnostic.CMV isolation from amniotic fluid has been recognized as the gold standard for prenatal diagnosis of fetal CMV infection.so you can consult your doctor for amniocentesis after 21st week.
hope this is helpful to you. take care
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