Hello, Thanks for posting this question in HCM Let me explain you that a given medical symptom is due mainly to various causes and the aim of the physician is to find out the exact cause and deal accordingly rather than simple assumption. Back to your questions i understand that you have headache which is diagnosed as migraine, sinus and neuralgia and twitching. Let me deal your problem as follows 1. Let me tell you that headache can be due to various reasons like migraine, brain tumor, brain infections, problems in the blood vessel of the brain etc. One strong possibility is that the constellation of symptoms that you have described could be due to migraine. However, one has to understand that migraine is a diagnosis of exclusion that means other treatable conditions that result in headache which i have listed above need exclusion before the diagnosis of migraine is made. You will benefit from the following approach 1. During acute attack: this will improve with analgesics, sumatriptan nasal spray and relaxation, to avoid the precipitating factor like stress, coffee, perfumes which you have to find out. Avoid continuous use of laptop and take pause in between. Some people with migraine have visual sensitivity and this can trigger an attack. 2. Medicines that can modify the course of migraine will be helpful like valproate (not good in females), topiramate, propranolol, amitriptiline. Regarding the twitches in the multiple sites without any definite history of weakness of legs and hands is generally self-limiting and go away. If it persists allong with other symptoms like weakness of legs, hands, change in voice than you need neurological evaluation. Regarding the single episode of neuralgia, it is not clear from the data you have given what exactly and where exactly youy had the problem. There are many causes of neuralgia and the cause also will depend upon the sites of the body involved. This will require a neurological assessment and then a MRI scan depending upon the initial result of clinical evaluation. I feel that you have sinus infection in addition to all this. If you have persistent sinus infection despite medicine another option will be to undergo operation. Please meet a local ENT specialist. Overall, i feel that you don’t have any serious neurological problem as of now. You need to be jointly evaluated by a neurologist and ENT specialist who will guide you that way i have discussed Hope this will help you