** 1.Since in Systemic mastocytosis often termed as systemic mast cell disease [SMCD], there is infiltration of bone marrow, GIT, liver, spleen and skin thus first thing to look out for is : metastasis i.e. spread of cancer [since if it has spread thus it becomes highly unlikely to control the Infection through any system of Medicine. 2.symptoms of anemia, osteoporosis, itchy skin [urticaria] apart from mal absorption are also found during physical examination of SMCD. 3. before suggesting any treatment aspect, look out for blood picture since the combination of anemia, thrombocytopenia, hypoalbuminemia, and excess bone marrow blasts ( 5%) portends a poor prognosis. 4. Ayurvedic preparations can act as an adjuvant or a co-therapy along with chemotherapy or radiotherapy. PS. Rasayan {Immunomodulation] chikitsa : i.e. The cell-protective activity of drugs helps to improve comfort and the quality of life of individuals with cancer, mainly: trifla, guduchi, punarnava . daily use of amalaki which contains vitamin C and foof containing vitamin E helps retard the formation of cancer . use of onion, garlic and turmeric in the diet, to some extent depress the growth and suppress the formation of cancer cells in the body. PS. According to clinical studies, such drugs have shown very impressive effects on protecting body from the side effects (of chemo and radio therapies) like alopecia, nausea, constipation, anorexia and vomiting. The patients who receive Ayurvedic treatment along with chemotherapy have shown more regularity in maintaining the chemotherapy cycles as the hematological levels can be maintained up to a normal state. More than 50 research studies on cancer carried out at various post-graduate institutes, have shown that Ayurvedic preparations are very effective as chemo-preventive and radio-preventive agents.