Hello dear, Thank you for your contact to health care magic. I read and understand your concern. I am Dr Arun Tank answering your concern. Yes, allergic reaction and trypanosoniasis can occur with the sandfly bites. If allergic reaction is severe at first time it will be more severe on second time. So in my advice you should avoid the sand fly bites second time. It may be life threatening on second time. This both condition can cause joint pain, pancytopenia and other symptoms. You should examine yourself for the trypanosomia. Peripheral blood examination and bone marrow exanination can be helpful for diagnosis. Bone marrow examination can help diagnose the various morphological forms of the parasites. Once you treat the condition all the problem will be solved. Please use repellant, net and personal protective equipment for the prevention. I will be happy to answer your further concern on bit.ly/DrArun. Thank you, Dr Arun Tank Infectious diseases specialist, HCM.