Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
180 Doctors are Online

Is there a permanent treatment for Glanzmans Thrombostania ?

Dear Sir, my wife is suffering from Glanzmans Thrombostania since 1992, we married in 1994 till childless, tried IVF 8 times with Dr. Malpani, Dr. Upadhaya and Dr. SV Desai of Ghatkoper but result was negative. Pl advice me weather I should further try or not. and weather any permanent treatment is available for the decease. pl advice
Asked On : Mon, 25 Apr 2011
Answers:  4 Views:  136
Report Abuse
Share on Facebook
Share on Twitter
Share on Google+
General & Family Physician 's  Response
Glanzmann thrombasthenia is a genetic platelet disorder in which the platelet glycoprotein IIb/IIIa (GP IIb/IIIa) complex is either deficient or present but dysfunctional. The genes of both of these proteins are on chromosome 17, and 50% activity of each protein is enough to support normal platelet aggregation. Defects in the GP IIb/IIIa complex leads to defective platelet aggregation and subsequent bleeding.

Glanzmann thrombasthenia is rare and it is inherited in an autosomal recessive pattern. The disorder was first described by Dr. Eduard Glanzmann in 1918.
Answered: Fri, 6 May 2011
I find this answer helpful
Pediatrician Dr. Suryakanta Baraha's  Response
Glanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder. There is an absence of glycoprotein (GP) IIb/IIIa on the platelet membrane which causes reduced platelet aggregation with a defective platelet haemostatic plug formation.Pregnancy and delivery is rare in these patients and is associated with a high risk of severe haemorrhage
1-Once pregnancy occurs, patients
may develop bleeding during pregnancy for
obstetric causes, intrapartum or postpartum
2-Pregnancy in patients with Glanzmann's
thrombasthenia is rare,
but it is life-threatening
for both the patient and her fetus.
The fetal risk
is related to fetal immune thrombocytopenia
induced by the transplacental passage of the
maternal IgG anti-GPIIb-IIIa isoantibodies, In
case of the severe fetal thrombocytopenia, there
is a risk of fetal intracranial hemorrhage.
3-A team work, the obstetrician and the
hematologist is essential in deciding the best
option and best time to interfere in this high- risk
group of patients.
so mr pithabas better take consultation of both gynecologist and hematologist.
Answered: Fri, 6 May 2011
I find this answer helpful
Sports Medicine Specialist Dr. Abhay Dikshit's  Response
The disease is a congenital platelate disease.
As such it has no connection with infertility.
The bleeding tendancy increases because ofthe disease.
It is a genetic disease. So genetic counselling & testing is of much help before trying for pregnancy.
Answered: Sat, 7 May 2011
I find this answer helpful
  User's Response
i think there is no relation between Glanzmans Thrombostania and childless
Answered: Thu, 28 Apr 2011
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]

Related questions you may be interested in


Loading Online Doctors....
© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor