My 57 year old female friend has breast cancer. Following intensive chemo the HERS2 positive shrunk from 2.3 cm to 1.1 cm. Is that significant or not? The HERS2 negative tumor she was told has not shrunk significantly. She has had severe reactions to chemo - lethargy, blisters, nausea. She is ticketed for surgery and a check of the sentinel node. Does it sound like she is not making good progress via the chemo? What is your opinion?