Hello, I understand your concern. I am Dr. Arun Tank, infectious diseases specialist, answering your query. Yes long term HPV can cause papilloma. If the HPV not attended in time it can lead to papilloma. Please start treatment of papilloma, at earliest other wise it may turn in to papilloma. I will be happy to answer your further concern, you can ask me on bit.ly/DrArun. Thank you. Dr Arun Tank Infectious diseases specialist.