Hi. Thanks for posting your concern at HCM Roaccuatne is Isotretinoin and is used by dermatologists around the world for the most severe acne. Although it has along list of side effects but most of them are minor like dryness and chelitis and reversible. Moreover it is a very useful drug in my practice and i have found wonderful results with it. Management of acne required diligence and patience both on the part of the patient and doctor General measures: Use a mild cleanser like cetaphil twice daily Avoid all the regular use creams, moisturizers, sunscreens that you may be using for the time being till you are on anti-acne treatment. Avoid taking facials. Avoid picking your acne. Use an Anti-dandruff shampoo since acne is worsened by dandruff. Specific Anti-acne treatment: Oral Antibiotics: For inflammatory acne(papules and pustules) i advice my patients to start with one of the oral antibiotics leither Azithromycin/ Doxycycline OR Minocycline. Topical treatment: Is a valuable adjunct to any form of acne treatment. Mainly two classes of drugs are used topically 1)Topical Antibacterials: Dermatologists around the world prescribe topical gels/creams containing topical antibiotics like either clindamycin 1%/ benzoyl peroxide 2.5% OR Nadifloxacin during the day time. 2)Topical Retinoids: Either Adapalene 0.1%/ Tretinoin 0.025% OR Azaleic acid (10%/20%) at bed time. If you dont want to take Roaccutane i would recommend Oral antibiotics along with topical antiacne gels/creams. Hope this information helps. take care regards