I am concerned about taking plavix and metformin. I have just completed a series of visits to Mayo Clinic. I have a medical history of diabetes 2 , multiple kidney stone formation, migraines, mucositis, lymphocitic colitis, acute idiopathic restrictive pericarditis,. I have a family history of strokes. In 2011 I had an ischemic event on the left side of my head, outer obstructed middle vein controlling the eye alignment. In 3 months the condition was gone. I have been informed that earlier MRI s indicated ischemic events. I was placed on plavix by opthamologists . Mayo discontined the plavix and 80 miligram aspirin during the evalatuiions October 2013 through February 2014 due to digestive difficulties. I have not gotten a straight answer whether to return to 80 miligram aspirin and plavix. K L Stutzman