There are no known major interactions between Glucosamine chondroitin dietary supplement with Paxil (paroxetine) and Claritin (loratidine). But being a dietary supplement, they don t undergo rigorous clinical testing process. Therefore, the full profile of interactions aren t available and has to be determined on an individual basis. I would not prescribe dietary herbal supplements to my patients as any side effects cannot be predicted. You can discuss the above points with your physician and take a decision on your medications. I hope the above information helps you. Thanks for writing into healthcaremagic. Have a wonderful day.