Hi & Welcome. It is not safe to take Curcumin while on Xarelto. Xarelto (Rivaroxaban) is an anticlotting medication ( blood thinner ) used to prevent blood clots from forming due to a certain irregular heartbeat (atrial fibrillation) or after hip or knee replacement surgery. Its most common side effects include easy easy bruising or minor bleeding (such as nosebleed, bleeding from cuts). Although curcumin has anti-inflammatory properties, it can magnify the anti-clotting effects of Xarelto as mentioned above if taken together thus resulting in increased risk of bleeding or bruising. As such there is no anticoagulant that can be taken safely while on Curcumin. So, in view of the above, it is better to avoid taking curcumin while on Xarelto. Hope these answer your query.