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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is It Safe To Continue With The Present Prescriptions?

My doctor has prescribed Simvastatin 40mg and Amlodipine 10 mg but I have read that a recent study suggests that Simvastatin should be limited to 20mg if taken together with Amlodipine. Is it safe for me to continue with my present prescription.

William R Shakespeare
Tue, 11 Aug 2015
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General & Family Physician,  's  Response
Hello, I really appreciate your concern. It is scientifically proven that with amlodipine, concentration of simvastatin increases significantly. So it is recommended to reduce the dose of simvastatin to 20 mg with 10 mg amlodipine to avoid side effects of simvastatin like myopathy. Fluvastatin, pravastatin, and rosuvastatin are probably safer alternatives in patients receiving amlodipine. So kindly consult your treating physician and draw his/her attention to this matter to set the doses accordingly.
Hope my answer has solved your query. Take Care.
Thank you.
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Is It Safe To Continue With The Present Prescriptions?

Hello, I really appreciate your concern. It is scientifically proven that with amlodipine, concentration of simvastatin increases significantly. So it is recommended to reduce the dose of simvastatin to 20 mg with 10 mg amlodipine to avoid side effects of simvastatin like myopathy. Fluvastatin, pravastatin, and rosuvastatin are probably safer alternatives in patients receiving amlodipine. So kindly consult your treating physician and draw his/her attention to this matter to set the doses accordingly. Hope my answer has solved your query. Take Care. Thank you.