Hi, Yes, it is not safe to take these two medications together. Taking oxycodone while on cipralex can increase the risk of a serious condition called the serotonin syndrome which is characterized by symptoms such as confusion, hallucinations, seizures, increased heart rate and blood pressure fever, excessive sweating, blurred vision, muscle stiffness, tremor, stomach cramp, nausea, vomiting, and diarrhea. In its severe form it may result in coma and even death. You can ask your doctor for an alternate effective but a safer analgesic medication while taking cipralex. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician