Can immunotherapy be used to treat either instead of chemo, or in combination with chemo for Invasive Ductal Carcinoma? Left breast- Positive Estrogen and Progesterine, HER2 negative. Ki-67 60% 60. I have a high risk family history of breast cancer. One doctor suggests surgery prior to chemo and radiation - he scoffed when I asked about immunotherapy. The second doctor suggests chemo prior to surgery and radiation. I didn t ask her about immunotherapy. I have since learned that it can be used for certain cancers. Could it be used with IDC either in place of chemo, or combined? I was diagnosed late March. I am an otherwise a healthy 60 year old. I was doing natural body building up until 4 years ago. I regret I stopped the intense workouts and strict diet. Sugar is my enemy. I have totally cut it out now and I m ready to go back to my trainer. I ve lost a ton of muscle. I m surprised that doctors are telling me I appear to have good muscle tone. I guess it depends on where who you re comparing me to. Thank you for your help.