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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is dipyridamole concurrent with doxorubicin taken to prevent drug resistance to MDR?

Have you heard of taking dipirydamole (cardoxin) concurrent with doxorubicin to prevent (circumvent) drug resistance or MDR? have you ever prescribed dipirydamole any of your patients taking this chemo drug? if so why not? Any other tricks up your sleeve to prevent or reverse this bane of chemotherapy called drug resistance or MDR? Looking foreward to your answer
Mon, 25 Feb 2019
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Internal Medicine Specialist 's  Response
Hi,

Dipyridamole (DPM) is able to increase and retain the intracellular levels of DOX (doxorubicin) & can markedly enhance the cytotoxicity of DOX, and hence may have possible clinical application.

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Tushar Kanti Biswas,
Internal Medicine Specialist
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Is dipyridamole concurrent with doxorubicin taken to prevent drug resistance to MDR?

Hi, Dipyridamole (DPM) is able to increase and retain the intracellular levels of DOX (doxorubicin) & can markedly enhance the cytotoxicity of DOX, and hence may have possible clinical application. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Tushar Kanti Biswas, Internal Medicine Specialist