Hi & Welcome. I appreciate your concern for the safety of Amlodipine. Amlodipine is a calcium channel blocker used in the treatment of various conditions like high BP, angina pectoris, etc. The most common side effects that can occur with its use include: Constipation, swelling of ankles (oedema), increase heart beat, headache, dizziness, and sleep disturbances. Depression is not associated with the use of Amlodipine. You are advised to consult a neurologist for proper evaluation and probable use of antidepressant drugs like SSRI for your symptoms of depression. Hope this answers your query.