Hi, Are you an alcoholic? Are you a smoker? How old are you? Yes, as you told pancreas, liver, genital tract, bowel and salivary glands problems it may be elevated. Macroamylasemia is a benign condition in which the amylase molecule binds with a large complex molecule (e.g., immunoglobulin, polysaccharide), thereby decreasing renal clearance and prolonging its half-life. Amylase increases may occur postoperatively. Ketoacidosis that results in increased S-type and P-type isoamylases or nonketotic acidosis that results in increased S-type isoamylase, can cause hyperamylasemia. Treatment depends upon the cause. Elevation may be compared to lipase. The amylase-to-creatinine clearance ratio (ACR) can help differentiate acute pancreatitis from other conditions. An ACR of greater than 5% suggests acute pancreatitis. Avoid alcohol intake and smoking. Check for autoimmune diseases like Sjogren s syndrome or SLE. Please consult your gastroenterologist, he will examine and treat you accordingly. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Penchila Prasad Kandikattu, Internal Medicine Specialist