Hello, Thanks for the query. Progesterone is actually required for proper maintenance of pregnancy in the early part. So it is used either as oral or inravaginal drug. There is really no reason to worry about it causing any harm. as the following lines explain: Available evidence suggests that the most common forms of progesterone supplementation are safe in early pregnancy. Earlier reports of a possible link between exposure to progestogens and an increased risk for hypospadias have been discounted since the few cases involved were with high doses of progestins derived from androgens. The FDA conducted a thorough review of the relevant published studies, and they found that there is no increase in Congenital anomalies including genital abnormalities in male or female infants resulting form maternal exposure to progesterone or 17 α- hydroxyprogesterone in early pregnancy . I hope I have cleared your doubt. Thanks.