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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Losartan HCTZ the right medicine for hypertension?

What is the best hypertension drug for patients with low gfr (17)? I am taking Losartan-hctz 100/12.5mg currently. The site says in rare cases it can cause kidney failure: In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. http://www.rxlist.com/hyzaar-drug/patient-images-side-effects.htm
Wed, 28 Nov 2018
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General & Family Physician 's  Response
Hello,

The adverse kidney effects of HCTZ/Losartan are extremely rare. However, in patients with reduced kidney function, the anti-hypertensive of choice is ACE (Angiotensin converting enzyme) inhibitors like Captopril, Enalapril etc. The ACE inhibitors reduce blood pressure along with the added benefit of reno-protective effect.

Losartan can also be considered to be a second choice next to ACE inhibitors. Please discuss the need for reconsidering the antihypertensives with your treating physician.

Hope this answers your question. Please let me know if I can assist you further.

Regards,
Dr. Lekshmi Rita Venugopal, General & Family Physician
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Is Losartan HCTZ the right medicine for hypertension?

Hello, The adverse kidney effects of HCTZ/Losartan are extremely rare. However, in patients with reduced kidney function, the anti-hypertensive of choice is ACE (Angiotensin converting enzyme) inhibitors like Captopril, Enalapril etc. The ACE inhibitors reduce blood pressure along with the added benefit of reno-protective effect. Losartan can also be considered to be a second choice next to ACE inhibitors. Please discuss the need for reconsidering the antihypertensives with your treating physician. Hope this answers your question. Please let me know if I can assist you further. Regards, Dr. Lekshmi Rita Venugopal, General & Family Physician