cannot say in your particular (arginine) case. But arginine is a normal constiuent of food. Food is usually taken even with hypertension. There are actual interactions between food and HCTZ (salt). Different formulations of arginine have different salt contents and occaisionally have truly surprising things mixed into them that could be quite dangerous. The arginine itself, no not dangerous. A couple other points. Amino acids have been shown helpful in increasing lean body mass and complicated ones (arginine is one) are a bit more important than simple ones (glycine.. found in low quality protein). BUT whey, meat, and other proteins are more effective, more controlled manufacturing, more reliable, more studied than ONE particular amino acid. Taking a food for losing weight is just plain silly. That never works. The fundamental problem is the particular part of the brain involved with addiction/compulsive behavior. First of all it distorts the entire perception of the problem both by those with weight problems and also those studying it. It is the part of the brain that makes us (and cats and addiction researchers and diet book writers) chase after bright shiney things like pill bottles and ignore the background (how much we eat; how little we exercise). Instead an approach of looking at the background: where do we mess up? and then fixing it by avoiding the problem, substituting other things, or true behavior modification techniques will work and arginine won t unless it is in place of food with calories.