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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is 20mg Of Benadon Sufficient In The Treatment Process Of TB?

Doctor im doing TB treatment. And im on the 2 last month to complete 6 month of treatment. I was taking a kind of vitamin B6 before in which i had to take 3 tablet a day after meal. Now im in india and i went for control and the doctor prescribed me another kind of V. B6 benadon to take alf tablet in d morning after meal. Is it not too litle? Since i was taking 3 tablets p day abd to change radically to half of benadon40 per day? Please help
Mon, 11 Apr 2016
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General & Family Physician,  's  Response
Hi & Welcome to HCM.
Peripheral neuritis (inflamed nerves) is an important side effect of anti-TB medication Isoniazide (INH) which is due to deficiency of Vitamin B6 (Pyridoxine).
It is uncommon at conventional INH dosage but more common in the malnourished, diabetes, HIV, renal failure, alcoholism, pregnant and breastfeeding women. This side effect is dose related.
Pyridoxine supplementation is recommended only in such conditions to prevent neuritis.
The INH-induced peripheral neuropathy can be prevented by supplementing 10 mg Pyridoxine for every 100 mg INH or in the dose of 25-50 mg in high risk patients as mentioned above.
Hence, in view of the above the prescribed dose should be between 25-50 mg/day. You are also advised to take fruits and vegetables which are also a good source of vitamins including Pyridoxine.
Hope the suggestions given above would be useful.
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Is 20mg Of Benadon Sufficient In The Treatment Process Of TB?

Hi & Welcome to HCM. Peripheral neuritis (inflamed nerves) is an important side effect of anti-TB medication Isoniazide (INH) which is due to deficiency of Vitamin B6 (Pyridoxine). It is uncommon at conventional INH dosage but more common in the malnourished, diabetes, HIV, renal failure, alcoholism, pregnant and breastfeeding women. This side effect is dose related. Pyridoxine supplementation is recommended only in such conditions to prevent neuritis. The INH-induced peripheral neuropathy can be prevented by supplementing 10 mg Pyridoxine for every 100 mg INH or in the dose of 25-50 mg in high risk patients as mentioned above. Hence, in view of the above the prescribed dose should be between 25-50 mg/day. You are also advised to take fruits and vegetables which are also a good source of vitamins including Pyridoxine. Hope the suggestions given above would be useful.