1.Acetylcholinestearse (AChE) also known as acetylhydrolase causes hydrolysis of acetylcholine at neuromuscular junction
and cholinergic brain synapses, where it causes termination of synaptic activity.
2. During neuro transmission, acetylcholine is released from the nerves and binds to acetylcholine receptors on the post synaptic membrane to relay the signal, Acetylcholinesterase
also located on the post synaptic membrane terminates the signal by hydrolyzing Acetylcholine. This choline is again taken up by the pre-synaptic nerve and acetylcholine is again synthesized.
3. Now if for any reason this acetylcholinesterase is inhibited or not produced in sufficient amount this will result in accumulation of acetylcholine and acetylcholine is an EXCITATORY neurotransmitter
thus resulting in muscular paralysis
, convulsions, bronchial constriction and death due to asphyxia.
4. best known example is organophosphorus poisoning
5. Acetylcholinesterase inhibitors are used to treat Alzheimer's Patients.