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If the body couldn't produce acetylcholinesterase. What would happen?

If the body couldn't produce acetylcholinesterase. What would happen?
Asked On : Tue, 15 Feb 2011
Answers:  2 Views:  769
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Ayurveda Specialist 's  Response
1.Acetylcholinestearse (AChE) also known as acetylhydrolase causes hydrolysis of acetylcholine at neuromuscular junction and cholinergic brain synapses, where it causes termination of synaptic activity.
2. During neuro transmission, acetylcholine is released from the nerves and binds to acetylcholine receptors on the post synaptic membrane to relay the signal, Acetylcholinesterase also located on the post synaptic membrane terminates the signal by hydrolyzing Acetylcholine. This choline is again taken up by the pre-synaptic nerve and acetylcholine is again synthesized.
3. Now if for any reason this acetylcholinesterase is inhibited or not produced in sufficient amount this will result in accumulation of acetylcholine and acetylcholine is an EXCITATORY neurotransmitter thus resulting in muscular paralysis, convulsions, bronchial constriction and death due to asphyxia.
4. best known example is organophosphorus poisoning.
5. Acetylcholinesterase inhibitors are used to treat Alzheimer's Patients.
Answered: Wed, 3 Apr 2013
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Ayurveda Specialist Dr. Ram Mani Bhandari's  Response
Acetylcholinesterase: An enzyme that breaks down the neurotransmitter acetylcholine at the synaptic cleft (the space between two nerve cells) so the next nerve impulse can be transmitted across the synaptic gap.
if our body connot produce acetycholinesterase in the synaptic cleft wouldresult in
A. a decrease in acetylcholine production by the motorneuron
B. continuous stimulation of the postsynaptic membrane
C. rapid degradation of acetylcholine
D. relaxation of the muscle
E. continous stimulation of the presynaptic membrane

Answered: Tue, 29 Mar 2011
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