I have been diagnosed with moderate aortic valve stenosis. Can this condition cause swelling and redness in my legs from the calf portion down to the ankle in both legs? I am currently taking Furosemide -- somedays I take 10 mg. other days 20 mg. I am also on Rosuvastatin for high cholesteral (236) and am taking 200 mg. of Co-Q-10 mineral supplement twice a day. I am also on Pantoprazole for acid reflux. Are these medications I am taking compatible with each other? The main side effect I am having from Rosuvastatin is muscle weakness. The main side effect from Furosemide seems to be redness, itching and tingling of hands and fingers. I am facing total knee replacement surgery on my right knee on June 13, 2018.