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Dr. Andrew Rynne

Family Physician

Exp 50 years

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I have a friend newly dx with multiple myeloma. They

I have a friend newly dx with multiple myeloma. They kept misdiagnosing her or not finding the root cause of symptoms until now. She is having kidney issues but they are starting her on chemo injections tomorrow. She will have chemo on mon and fri til Jan and then a BMT. What is the general survival rate for someone with this tx? 5yrs
Thu, 4 Oct 2018
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doctor1 MD

Dr., my 65 yr. old friend revealed that he was diagnosed several month ago with Multiple Myeloma. They have not done a bone marrow, which I thought unusual. He is experiencing back pain and it takes him a while to stand after sitting or lying down. He is an avid body builder. A comment from one of the persons mentioned Revlimid that her 78 yr old father has been given in low doses. The cancer has gone into remission. I am concerned that he is not getting the treatment he requires. The doctors he has seen are saying he has a bad aortic valve and herniated discs.

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i have a good friend with multiple myeloma. he suddenly has developed a raspy voice. He has multiple hairline fractures in his spine and ribs and has become quite stooped and seems to have difficulty breathing. Is the raspy voice related to the condition of his spine

doctor1 MD

HI Doctor, My Dad is suffering from multiple myeloma stage 3. Summery is as below. 60 Yrs. Male, known case of DMT2, Plasma cell myeloma with paraplegia on chemotherapy. Patient had presented with complaints of severe low back pain, radiate to both lower limb. He was hospitalized on 13/08/2013. His MRI L.S. spine was done which was suggestive of insular lesion L1 extending B/L neural foramina with hyper intense signal D5, D7, L4, S1 and right Acetabulam- under evaluation. Bone marrow biopsy taken on 22/08/2013 which was suggestive of plasma cell myeloma, blood investigation- Light Chain Myeloma stage III and newly detected DM-T2. Heamato-oncologist opinion was taken, who advised chemotherapy ( Dose- 30 GY/10, Site- Dorsolumbar spine ( D10 to L3 Vertebrae, position-supine with orfit cast for immobilization ,No of fields-2 field with subfields, technique-palliative 2 D RT with 6MV photon on linear accelerator, Duration -2 weeks. From 4/9/2013 to 17/9/2013) and continue scheduled chemotherapy. He responded well with given this treatment.But he again detoriated and hospitalized on 21/10/2013 with complaints of paraplegia. He investigated urine for bence jones protein was negative and MRI LS SPINE was done, which revealed multiple scattered well defined altered marrow lesions of varying sizes are seen in vertebral bodies of spine at multiple levels, few of the lesion are showing involvement of posterior elements as well. Similar lesions are seen in bones of pelvis and upper thigh as well. The lesion are causing erosion/lysis of affected bones. The most prominent of these lesions is seen in the L1 body resulting in its mild collapse. In addition abnormal enchancing posterior and lateral epidural soft tissue is seen from D4 to D8 levels causing moderate cord compression anteriorly mainly at D5, D6 and D7 levels. Overall findings appear consistent with multiple myeloma. In comparison with previous latest MRI the lesions appear better defind with prominent fatty changes in rest of marrow of spine. Previously seen epidural soft tissue at D11 to L1 is almost completely regressed however there is new appearance of epidural soft tissue from D4 to D8 with moderate cord compression. Suggest correlation with other relevant parameters and SOS follow up. Hence 1 cycle of chemotherapy given on 26/10/2013 (INJ- BORTEZOMIB 2.5 mg) and Radiotherapy on 23/10/2013 and 24/10/2013. But he does not responded with the treatment.

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