Hello, These antibodies are indeed associated with lupus but the diagnosis of lupus requires a more detailed approach and assessment of many parameters. Various antibodies may occur more frequently in certain families but lupus itself is not a genetically determined disease. This means that your relatives may have a slightly higher risk for autoimmune disorders but the risk for lupus is still low as lupus is a very rare disorder. To make it more clear, imagine that lupus may occur in approximately 15 out of 100,000 individuals and even if someone has a higher risk than others (e.g: double or triple risk), the absolute risk would still be low. I am not sure whether you wanted me to get into more details in this subject or not. If you have more questions please let me know and I ll be glad to answer them. I hope I ve answered your question. Regards, Dr. Panagiotis Zografakis, Internal Medicine Specialist