How to reduce reactive oxygen species level ?

HI... PLEASE GO THROUGH THIS REPORT AND HELP ME IN THIS REGARD... ADVANCED ANDROLOGY LABORATORY COMPUTER ASSISTED SPERM ASSESSMENT (CASA) Name     MR. SURESH KUMAR.S      Age     34 Yrs     Hosp No      Abstinence days      03     Volume → 2.6 ml      Time of Collection     09.40 AM     Time of Evaluation     10.10 AM     Spillage:     No Fructose → Positive     Pus cells→ 01/hpf Not Significant      Ph → 8.0     Liquefaction → Normal     Live → 39 %     Dead → 61 % CONCENTRATION ASSESSMENT (5th percentile value) Total Ejaculate Millions      218 million Total Ejaculate: Normal (5th per: 40 75th per: 120) Sperm Conc. (millions / ml     84 mill/ml                 MOTILITY ASSESSMENT (5th percentile value) Sperm Motility     1 Hr     2 Hrs Total Progressive       27%      12% Non Progressive       08%      10% Immotile       65%      78%            Total motility (Total Progressive + Non Progressive)     35%     22 % 1 Hour Total motility: Sub Normal (5th Per: 42 75th Per: 50) Advanced CASA parameters     Micro mt/sec Straight Line Velocity-VSL      00.0 Curvilinear Velocity –VCL      28.0 Hyper activation –H max assay      00.0 Advanced Total Progressive Motility Assessment (CASMA) Rapid Progressive      00% Slow Progressive      27% Advanced Total progressive motility: Sub Normal (5th Per: 10      75th Per: 15) MORPHOLOGY ASSESSMENT (TYGERBERG KRUGER) (5th percentile value) Morphology      % Normal Forms      02% Over all Defects      98% Sperm Morphology: Sub Normal (5th Per: 4 75th Per: 9) Head Defects      67% Mid Piece and Neck Defects      20% Tail Defects      11% Multiple Defects      33% Excessive residual cytoplasm (ERC)      03% Ex. residual cytoplasm: Not Significant ADVANCED ANDROLOGY LABORATORY ADDITIONAL PARAMETER ASSESSMENT Round cells: Nil      Bacteria: Not significant RBC: Nil Agglutination: Nil Cellular debris: Not significant Special Comment : Final Impression- ASTHENOTERATOZOOSPERMIA 1. Terminology used in final impression is on the basis of total ejaculate concentration, motility & morphology. Additional parameter reported needs to be evaluated independently by the physician. 2. Impression based on 5th percentile value, however, 75th percentile value may be optimum and treatment plan may be suitably decided by the physician. 3. 75th percentile value was decided optimum instead of 90th percentile by our clinical database and international opinion - to avoid too large an indeterminate group. CASA: Computerised semen analysis is done with sperm class analyzer (http://www.spermclassanalyzer.com/) which provides fast, accurate & objectively repeatable results. This sophisticated software reports concentration, motility, morphology, vitality & DNA Fragmentation Index with unmatched accuracy with inbuilt QC/ QA checks. Useful information: Percentile value represents a range where the upper and lower reference limits (obtained by high quality reference data - WHO 5th manual and Asian Journal of Andrology 2010) define threshold levels of minimum and optimal numbers. Statistically, if the threshold levels are below 5th percentile pregnancy possibilities are extremely low and similarly if the levels are above 75th percentile pregnancy possibilities reach near normal population levels. The reporting format (first in India) ensures planning of cost effective solutions for male fertility problems. Note: CASA - Semen Analysis is a guide to fertility and facilitates planning management. The report needs to be interpreted by the treating physician with corresponding clinical factors and is not a proof of fertility. CASA sperm motility     CASA sperm morphology       ADVANCED ANDROLOGY LABORATORY 5th and 75th percentile reference values Volume     1.7 ml – 2.0 ml Ph      7.2 Liquefaction     30 min Vitality      58 % of cells Agglutination – MAR test      Fructose     Positive White Blood cells      Peroxidase-positive leukocytes       Seminal neutral glucosidase      Greater than or equal to 20 (mU/ejaculate)      Test       5th Percentile value (Minimum numbers - WHO 5th manual)       75th Percentile value (Optimum numbers) Sperm Concentration Total Ejaculate      40 mill for total ejaculate      120 Million Sperm Concentration / ml      16 mil / ml      40 Million Motility Progressive       33 %       40 % Total Motility (Progressive + Non Progressive)       42 %       50 %            Advanced Total Motility           Rapid Progressive      10 %     15 % Slow Progressive     23 %     25 %            Morphology      4% Normal forms       9 % Acrosome Intactness Index      50 %      Excessive residual cytoplasm (ERC)                 Testicular sperm producing capacity per day per ml of testicular volume      0.25 million     1.25 million            VSL     17-67 micro mt/sec      VCL     25-100micromt/sec      H max assay     6.8 + 1.7      QC / QA: Quality assurance (QA) and Quality control (QC) as per WHO 5th manual are strictly followed as Semen Analysis is a multivariate sample. Volume by weight/ computer assisted motility & morphology-CASMA & Peroxides stain for WBC with Tygerberg-Kruger morphology Recent Andrological advances: Advanced Andrology tests: Our advanced Andrology laboratory performs the following unique tests for the first time in India, to aid in specific management of Male Fertility problems: 1. DNA fragmentation index assessment for internal sperm defects - DFI 2. Sperm Functional Integrity assessment - SFI 3. Reactive Oxygen Species estimation - ROS The following tests will be introduced shortly: 1. Sperm Developmental Defect assessment – SDD 2. Biological Fertility Assessment (Men) - Spermatogenesis, Spermiogenesis & Functional fertility assessment - BFA (BFA is a comprehensive test which can predict fertility and identify the site of problems in men) – Contact your doctor or our lab for specific information. Copyright©2010 Ankur Dr. Vasan S S          Mr. Ganesan K K Director - UroAndrologist     Lab Manager Andrology team: Chaitra suma , Ashwini, Gomathi, Chitra ADVANCED ANDROLOGY LABORATORY SPERM FUNCTIONAL INTEGRITY ASSESMENT - SFI Flagellar Integrity - Hypo Osmotic Swelling                       41% Osmotic Swelling Test Normal               :      55 % spermatozoa with tail coiling Significance          :     This test is a good index of healthy spermatozoa. Clinical Relevance      : Decrease in HOS positive reaction indicates loss of viability                          hence may be an indication of degenerative changes occurring Spermiation defects - Acrosome Reaction after Ionophore Challenge 04%       ARIC Test Normal : 15 % spermatozoa with halos having mean diameter of 10 m Subnormal : 10-15 % spermatozoa with halos having mean diameter of 10 m Abnormal               :      Significance :      This test evaluates the functional status of sperm acrosome and is a good indicator of sperm’s ability to penetrate the oocyte. Clinical Relevance      : Decrease in Acrosome positive reaction indicate the                      Possibility of low or nil fertilization. Seminal Vesicle marker - Zinc concentration NA Zinc concentration Test Normal               :     2.4 μmoL per ejaculate Significance          : The function of the accessory gland is assessed by the content of Zinc and                     Zinc has been found to be critical to spermatogenesis Clinical Relevance      : Lower concentrations imply abnormal function of the accessory gland High zinc concentrations have been reported to depress oxygen uptake in the sperm celL.

i m a 46 year old male from jodhpur .in feb i was diagonosed with a problem occuring in lungs (fibrosis) at pgi chandigarh. from that day i m taking wysolone starting with 50mg n then reducing 10 mg by the period of 6 weeks .but till the date i cant see any relief in the problem.even the condition is critical before taking the medicine. my oxygene level remains at around 86 while working a little harder. is this ok to continue with it or should i go for some other things? and also suggest a diet control n some precautions while taking these types of medicines.