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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How To Interpret HBV Test Results To Decide Continuity Of Treatment?

Hi, my name is Qasim and I am 28 years old. I was suffered with HBV (chronic) and took therapy of Zeffix Lamivudine for 1 year and above. I also gave blood test three time during this year for PCR with profile. I explained my PCR and profile reports below and let me know should i stop taking Zeffix or continue it? Result: HBV DNA is NOT DETECTED in patient s sample Viral Load: Virus titre is less than the sensitivity of this assay Hepatitis B Profile: Surface Antigen (HBsAg)............ POSITIVE Surface Antibody (HBsAb)...........NEGATIVE Envelop Antigen (HBeAg)............NEGATIVE Envelope Antibody (HBeAb)........POSITIVE Core Antibody (HBcAb)...............POSITIVE Method used: Immunichromatographic Please Dr let me know what to to next? Should take or stop now? my email: YYYY@YYYY Thank s Regard s Qasim
Mon, 14 Jul 2014
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Infectious Diseases Specialist,  's  Response
Hello, Qasim, you have chronic HBV. Your test report is showing HBV DNA Negative. so you do not have active DNA in your blood which is notmeasurable. Your HbsAg antigen positive that shows you gone in chronic phase. HBeAg Negative means active DNA not Replicating. HbeAb Positive that is you have active antibodies against Hbe Antigen that will not allow Hbe to grow. HbcAb Positive means You have active antibodies against Core antigen. all your reports suggest that you are in chronic phase and do not have active replication. All my advice is that you should continue your treatment till you get HbsAb positive.
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How To Interpret HBV Test Results To Decide Continuity Of Treatment?

Hello, Qasim, you have chronic HBV. Your test report is showing HBV DNA Negative. so you do not have active DNA in your blood which is notmeasurable. Your HbsAg antigen positive that shows you gone in chronic phase. HBeAg Negative means active DNA not Replicating. HbeAb Positive that is you have active antibodies against Hbe Antigen that will not allow Hbe to grow. HbcAb Positive means You have active antibodies against Core antigen. all your reports suggest that you are in chronic phase and do not have active replication. All my advice is that you should continue your treatment till you get HbsAb positive.