My boyfriend has been on antidepressants for 17 years. He started with Prozac for a few years and it worked until he got off of them. When he tried to get back on it, it didn t work so he was given Zoloft. Zoloft worked for a few more years until he got off of ti. Then he tried to get back on it and it didn t work. The next thing he took was Paxil for a couple years and then got off of them and again, tried to go back and it didn t work. Lastly, he was given Prozac again and this time it worked until he got off them after being on it for a couple years. He was doing OK off of Prozac for 10 months until he had a stressful situation at work which brought him back into depression again. His doctor put him back on Prozac but it didn t work so he has tried Lexapro and Zoloft and none of them work now. His current symptoms are depression, anxiety, agitation, tearfulness (all day), restlessness. Now his current psychiatrist wants to put him on mood stabilizers which he s never taken before but he doesn t know if he truly is bipolar or not because he s also been taking Klonopin (1.5 mg at night) for the past 8 months and he believes that has caused his depression and anxiety to get worse when they wear off. His doctor says he now might be in mixed state and recommends mood stabilizers (Lamictal) but he s confused because it s been 9 months and wonders if it truly was bipolar would it really last that long and plus he s never had any highs (good) just majorly depressed and crying spells all day long, aggressiveness and agitation?