Thank you for the query. As per the information provided, the patient is 65 yrs old gentleman, a known diabetic (FBS- 162 mg%, PPBS-214 mg%) with renal impairment (Creatinine -1.70 mg%). I would like to enquire about his duration of Diabetes, the medications he takes and his HbAic levels. First and foremost, there are no medications to cure/reduce serum creatinine level. Uncontrolled Diabetes mellitus is associate with a number of long term complications, and Nephropathy is one of them. From the values of the blood sugar that you have provided, it isn t very well controlled, though a HbAic level is a better indicator. Apart of serum creatinine level (which is not a very reliable marker at times), Urine for spot ACR or 24 hrs urine for albumin excretion, can estimate the protein excretion (and hence the extent of nephropathy). Drugs like ACE inhibitors or ARBs can be given, to control the proteinuria (and this is beneficial in nephropathy). A USG of the kidney, can reveal whether, any chronic changes have occurred in them or not (like small, contracted kidneys). Some dietary changes need to be introduced, like protein modifications (reduced protein in diet approximately 0.8g/kg body weight). Intake of fluid/water depends on his hydration status. Usually at this stage intake of 2l of water per day is advised (if the patient is not in an overhydrated state) Acute causes of rise in creatinine need to ruled out like use of analgesics (pain-killers) or any infection. The total cholesterol of 117mg% is within acceptable range. Please do visit your physician/nephrologist, who can give an opinion, after thorough check-up of the patient and performing further investigations. Hope this helps you out. Regards, Dr. Ayusmati Thakur